The American lion (Panthera atrox) also known as the North American lion, American cave lion, or Naegele's giant jaguar was an extinct lion endemic to North America during the Pleistocene epoch (340,000 to 11,000 years ago), existing for about 0.33 million years and is one of the largest types of cat to have ever existed. It has shown to be a sister lineage to the European cave lion by genetic analysis.
- It played Domestic Cat in The Animals of the Ice Age Forest
- It played Rex in We're Back!: A Pleistocene Animal's Story
- It played Vitaly in Indonesia Series
- It played Entei in Pokémon (Samwei1234 Version)
- It played Albertosaurus in Warpath: Pleistocene Park, Pleistocene Park: Operation Genesis and Pleistocene World Evolution
- It played Valka's Bewilderbeest in How to Train Your Felid 2
- They played Alex, Zuba, and Florrie in the Madagascar Series (Samwei1234 Version) and Madagascar (NatureRules1/GavenLovesAnimals Style) (Version 2)
- It played Tyrannosaurus Rex in Walking With Animals (Samwei1234 Version)
- It played Ice Bear in We Bare Lions and We Bare Lions: The Movie
- It played Charlie in We Bare Pleistocene Animals and We Bare Pleistocene Animals: The Movie
- It played Ricky Plesuski in Pleistocene Animals, Inc.
- It played as Carnotaurus in Cenozoic Park Franchise
- It played Michelangelo in Teenage Mutant Ninja Lions
- They played Zac (Merman) and Evie McLaren (Mermaid) in Mako Pleistocene Animals and Pleistocene: Just Add Animals
- It played Emma (Mermaid) in Mako Lions