Angelica Charlotte Pickles is the nauseating and unbearable female antagonist from Rugrats and who bullies and bosses her younger costars around and treats them as her slaves. Because she is older than the babies are, she is able to talk to the adult characters on the series (while the babies can only communicate with each other and Angelica) which she uses to take advantage of them. Angelica can best be described as the spoiled, vain, sarcastic, selfish, bratty and antagonistic cousin of Tommy and Dil Pickles. Despite her brattyness and greed, she is known for her frequently manipulating the babies for her own gain and calls them "dumb babies", and thinks she is smarter than them. When the character Susie Carmichael was introduced, she was soon favored among the babies, causing Angelica to start a rivalry with her. She'll say and do anything to get what she wants, even though it normally just gets her into, most of the time, serious trouble.
However, deep beneath her tough shell, she does really care about her younger playmates at times. For example in Rugrats in Paris: The Movie, everyone at the wedding, even Angelica, was shocked when film's main antagonist, Coco LaBouche revealed her true nature towards the babies by knocking them down as she pulled them off the train of her wedding dress, yelling "Off Ze gown, you revolting carpet mice!" In retaliation, Angelica tells the evil woman off, "Listen, lady! Nobody messes with my dumb babies 'cept me!" and she stomps on the dress, which rips and exposes Coco's underpants, and the cruel and horrible woman runs away, sobbing at her humiliating yet well-deserved punishment as tourists take pictures of her underwear. — Angelica revealed the truth to that evil woman's boss Mr. Yamaguchi about her lies claiming that she had a kid's heart (when in reality, she was a cruel, heartless child-hating monster) and was about to marry Chuckie's widowed father Chaz so that she could receive the promotion to become president of EuroReptar Land. This leads to Mr. Yamaguchi, appalled at this deceit, fires her from EuroReptar Land.
Angelica has shoulder-length blonde hair in two pigtails tied with purple bows and wears a reddish-orange long-sleeved blouse with flared cuffs, a purple knee-length sleeveless dress, blue and green polka-dotted tights, orange ankle-high socks, purple and white sneakers, diapers (Season 1 only), frilly panties (Season 2 onwards since she is now potty trained) and a matching camisole.
- Tommy and Dil Pickles (cousins), Chuckie and Kimi Finster, Phil and Lil DeVille, Susie Carmichael (sometimes), Alisa Carmichael (sometimes), Buster Carmichael (sometimes), Edwin Carmichael (sometimes), Harold Frumpkin (sometimes), Timmy, Todd, Ty, Terry and Teddy McNulty (sometimes), Brody, Dean, Jean-Claude(Angelica's In Love), Debbie Thornberry
- Susie Carmichael (sometimes), Scar Snout, Coco LaBouche and her assistant Jean-Claude (Rugrats In Paris: The Movie), The Bully (Smell of Success), Josh Evans, Siri
- ''Bout time you tinkleheads came to the rescue.''
- "Listen, lady! Nobody messes with my dumb babies 'cept me!"
- "Hey lady, looks like your plan to trick Mr. Yummy-sushi didn't work after all."
- She is portrayed by Stewie Griffin in Rugrats (female version)
- She is portrayed by Brittany Miller
- She is portrayed by Lola Loud
- She is portrayed by Shrieky
- She is portrayed by Darla Dimple
- She is portrayed by D.W. Read
- She is portrayed by Mertle Edmonds
- She is portrayed by Lucy van Pelt
- She is portrayed by Princess Morbucks
Cynthia doll Portrayals
- her Cynthia doll is portrayed by Rupert (Stewie Griffin's bear) in Rugrats (gender-bent version)
- Cynthia is portrayed by Barbie