Brenda Chance (voiced by Marilyn Schreffler) is the brunette Teen Angel on Captain Caveman and the Teen Angels and Dee-Dee's best friend. Like Shaggy, Brenda is a huge coward and hates solving mysteries, but unlike Shaggy, she is not a glutton. Brenda is always the one who ends up getting the short end of the stick and captured by the villains. Brenda is emotionally sensitive and is shy or nervous around scary people or strangers. Regardless of always going through a lot of slapstick and being bullied by the other angels, she's a valued member of the team and they love her just the same.
- Her appearances in the Stephen Squirrelsky and Friends' Movie Spoof Travels are Nikki's Adventures of Sing Along Songs Episode 9, Cloudy with a Chance of Meatballs, Finding Alvin, Animated Tale, The Forest Book 2, Nikki's Adventures of Sing Along Songs Episode 10, Madagascar, and Sleeping Beauty and will even be in more movie spoof travels.