Cast[]
- Thomas as Philip J. Fry - (because Thomas and Philip J. Fry are both the main protagonists in their show)
- Emily as Turanga Leela - (Emily has an interested crush on Thomas, just like Turanga Leela has an interested crush on Philip J. Fry)
- James as Bender Bending Rodríguez - (James and Bender Bending Rodríguez are both vain, rude, loud, and selfish)
- Rosie as Amy Kroker - (Rosie and Amy Kroker are both wear pink)
- Edward as Dr. John A. Zoidberg - (Thomas and Edward are good friends, just like Philip J. Fry and Dr. John A. Zoidberg are)
- Toby as Professor Hubert J. Farnsworth - (Toby and Professor Hubert J. Farnsworth are both old)
- Casey Jr. (from Disney's Dumbo/Casey Jr. and Friends) as Hermes Conrad - (Thomas and Casey Jr. are great friends, just like Philip J. Fry and Hermes Conrad are)
- Henry as Scruffy Scruffington - (Henry and Scruffy Scruffington are both clumsy)
- Bertie as Lord Nibbler - (Lord Nibbler's voice suits Bertie)
- Percy as Kif Kroker - (Percy and Kif Kroker are both wear green and best friends to Thomas and Philip J. Fry)
- Spencer as Zapp Brannigan - (Spencer and Zapp Brannigan are both pompous)
- Tillie (from The Little Engine That Could/Casey Jr. and Friends) as LaBarbara Conrad - (Tillie has an interested crush on Casey Jr., just like LaBarbara Conrad has an interested crush on Casey Jr.)
- Gordon as Calculon - (Gordon and Calculon are both pompous and proud)
- Molly as Monique - (Molly and Monique are both have names starting with "Mo")
- Duncan as Steve Castle - (Duncan and Steve Castle are both stubborn)
- Billy as Cubert J. Farnsworth - (Cubert J. Farnsworth's voice suits Billy)
- Toots (from Porky's Railroad/Casey Jr. and Friends) as Dwight Conrad
- Johnny (from The Brave Engineer/Casey Jr. and Friends) as Jonathan Frakes - (Johnny and Jonathan Frakes are both have names starting with "Jo")
- Hiro as George Takei - (Hiro and George Takei are both Japanese)
- Duck as Leonard Nimoy
- Oliver as William Shatner - (Oliver and William Shatner are both western)
- Elizabeth as Elizabeth Taylor - (Elizabeth and Elizabeth Taylor are both share the same names)
- Diesel 10 as Richard M. Nixon - (Diesel 10 is a real main villain in Thomas and the Magic Railroad)
- Daisy as Carol Miller - (Daisy and Carol Miller are both the main female villains)
- Jock (from RWS) as Barack Obama
- The Horrid Lorries as Walt, Larry, and Igner
- Hector as Beck - (Hector and Beck are both have the word 'ec' in the middle of their names)
- Diesel as Francis X. Clampazzo - (Diesel and Francis X. Clampazzo are both mean villains to Thomas and Philip J. Fry)
- Smudger as Roberto
- George as Lrrr - (George and Lrrr are both evil)
- Martha (made up yellow steamroller) as Ndnd
- Donald as Smitty
- Douglas as URL
- Mavis as Chief O'Manahan - (Chief O'Manahan's voice suits Mavis)
- Toad as Seymour Asses
- Lord Harry (from RWS) as Morbo
- Lady as Linda Van Schoonhoven - (Lady and Linda Van Schoonhoven are both named begins with the letter 'L')
- BoCo as Mayor C. Randall Poopenmeyer
- Bulgy as Beelzebot - (Bulgy and Beelzebot are both evil, wear red, and named begins with the letter 'B')
- Spamcan (from RWS) as Ogden Wernstrom - (Spamcan and Ogden Wernstrom are both mean and evil)
- Stepney as Hedonismbot
- Evil James (a fan-made Thomas character) as Flexo - (Evil James and Flexo are both evil and attempt to get rid of James and Bender Bending Rodríguez)
- Wilbert (from RWS) as Elzar
- 16 (from RWS) as Nudar
- Splatter and Dodge as Schlump and Fleb - (Splatter and Dodge are twins, just like Schlump and Fleb are)
- Sir Handel as Barbados Slim - (Sir Handel was rude in Season 4)
- Patrick as Stephen Hawking
- Cerberus (from The Little Engine That Could '2011 Film') as Robot Santa Claus - (Cerberus and Robot Santa Claus are both big, strong, evil, powerful, scary, and mean to Thomas and Philip J. Fry)
- S.C.Ruffey as H.G. Blob
- Derek as Al Gore
- Kermit the Frog (Muppets) as Slurms MacKenzie
- Silver Fish (from Porky's Railroad/Casey Jr. and Friends) as Melllvar - (Silver FIsh and Melllvar are both evil)
- Tracy (from The Little Engine That Could '2011 Film') as Michelle Jenkins
- Madge as Countess de la Roca
- Rheneas as Calculon's Human Friend
- Bear (from RWS) as Boxy - (Bear and Boxy are both have four letters in one name and named begins with the letter 'B')
- Tex (from Theodore Tugboat) as Leo Wong
- Emily (from Theodore Tugboat) as Inez Wong
- Mallard (from RWS) as Lars Fillmore
- Green Arrow (from RWS) as Reverend Lionel Preacherbot
- Willy (from T&F/TMS) as Hypnotoad
- Sally Seaplane (from TUGS) as Sally - (Sally Seaplane and Sally are both share the same names)
- Top Hat (from TUGS) as Billionariebot
- Charlie as Tiny Tim
- Bill and Ben as Hobos - (Bill and Ben are twins, just like Hobos are)
- Eddie (from TTMA) as Ethan "Bubblegum" Tate - (Eddie and Ethan Bubblegum Tate are both named begins with the letter 'E')
- Henrietta as Crushinator
- Arry and Bert as Donbot and Joey Mousepad
- Salty as Mr. Panucci
- Fergus as David Duchovny
- Duke as Empeor Nikolai
- Flora as Umbriel