Cast[]
- James as Homer Simpson - (James and Homer Simpson are both vain, rude, grumpy and have their "me" in their middle names)
- Mavis as Marge Simpson - (Mavis and Marge Simpson are both have their names starting with "Ma" and girlfriends to James and Homer Simpson)
- Thomas as Bart Simpson - (Thomas and Bart Simpson are both young, cheeky, and son figures to Mavis and Marge Simpson)
- Rosie as Lisa Simpson - (Rosie and Lisa Simpson are both sisters of Thomas and Bart Simpson)
- Lady as Maggie Simpson - (Lady and Maggie Simpson are both little)
- Diesel 10 as Sideshow Bob - (Diesel 10 and Sideshow Bob are both evil and attempt to kill poor Thomas and Bart Simpson)
- Henry as Barney Gumble - (Henry and Barney Gumble are both fat, clumsy, and have names end with the letter "Y")
- Trevor as Professor Jonathan Frink
- Cranky as Krusty the Clown
- Toby as Grandpa Abe Simpson - (Toby and Grandpa Abe Simpson are both old)
- Duncan as Moe Szyslak - (Duncan and Moe Szyslak are both rude)
- Arry as Nelson Muntz
- Casey Jr. (from Disney's Dumbo/Casey Jr. and Friends) as Milhouse Van Houten - (Thomas and Casey Jr. are great friends, just like Bart Simpson and Milhouse Van Houten are)
- Tom and Jerry (from Tom and Jerry) as Itchy and Scratchy
- Percy as Ralph Wiggum - (Percy and Ralph Wiggum are both wimpy)
- Harvey as Groundskeeper Willie MacDougal - (Harvey and Groundskeeper Willie MacDougal are both scottish)
- Freddie as Martin Prince
- Proteus as Squeaky Voiced Teen
- Duke as Hans Moleman - (Duke and Hans Moleman are both old)
- Oliver as Chief Clancy Wiggum - (Oliver and Chief Clancy Wiggum are both western)
- Johnny Cuba (from TUGS) as Snake Jailbird - (Johnny Cuba and Snake Jailbird are both big and strong)