Karen is a member of the Plastics, and a student at North Shore High School. While she's shown to be extremely stupid and clueless in many occasions, she is easily influenced by Regina George and Gretchen Wieners. Despite her being portrayed as the 'dumb one' of the group, Karen is shown to be a good friend in some situations.
"So you from Africa, Why are you White?"
"I'm a Mouse, Duh!"
- Amanda Seyfried (Film)
- Kate Rockwell (Musical; debut)