The manticore is a legendary creature of Persian and Greek mythology, and is similar to the Egyptian sphinx. It has the body of a red lion, a human head with three rows of sharp teeth (like a shark), sometimes bat-like wings, and a trumpet-like voice. Other aspects of the creature vary from story to story. It may be horned, winged, or both. The tail is that of either a dragon, serpent or a scorpion, and it may shoot venomous spines to either paralyze or kill its victims. It devours its prey whole and leaves no clothes, bones, or possessions of the prey behind. The manticore is similar to the satyral, a legendary creature with "the body of a lion, the tail and horns of an antelope, and the face of an old man". Another similar creature is the lampago, a "man tiger". Dennys writes "Many have held the Manticore (with some latitude over its spelling), the Mantyger, the Satyral and the Lampago to be one and the same creature; others have differentiated them."
- It played as Gorgosaurus in Walking With Mythical Creatures
- It played HIM in The Powerpuff Mythical Creatures and The Powerpuff Mythical Creatures (2016)
- It played Bob Peterson in Mythical Creatures, Inc.
- It played Cynthia (Mermaid) in MerMythical Creatures (2003)
- It played Lion in Wally Trollman (Steven Universe)
- It played Nova in Super Mythical Creature Team Hyperforce Go!
- It played Lola Loud in The Mythical Creature House
- It played David in Totally Mythical Creatures