Rainbow Jones is Twilight'sSpaceStar17's movie-spoof of "Osmosis Jones".
- Rainbow Dash (My Little Pony: Friendship is Magic) as Osmosis Jones
- Pinkie Pie (My Little Pony: Friendship is Magic), Skunk (Skunk Fu!), Danny (Cats Don't Dance) and Godzilla (Monster Island Buddies) as Drix
- Twilight Sparkle (Me "My Little Pony: Friendship is Magic") as Leah Estrogen
- Venom (The Spectacular Spider-Man/Ultimate Spider-Man) as Thrax
- Jack Spicer (Xiaolin Showdown/Xiaolin Chronicles) as Mayor Phlegmming
- The Genie (Aladdin) as Chief of Police
- Mushu (Mulan) as Tom Colonic
- Arbiter (Halo Series) as Bruiser
- Scroop (Treasure Planet) as Spider Legs
- Pitch Black (Rise of The Guardians) as The Crime Boss
- Bolt (Bolt) as Flu Germ
- Venom's Villain Buddies as The Viruses
Community content is available under CC-BY-SA unless otherwise noted.