Cast[]
- Ariel as Jimmy Neutron
- Jim Hawkins as Carl Wheezer
- Molly Davis as Sheen Estevez
- Penny Proud as Cindy Vortex
- Andy Davis as Libby Folfax
- Melody as Goddard
- Queen Athena as Judy Neutron
- King Triton as Hugh Neutron
- Silica Terrell Keasler/Serena Taylor Keasler Tunestool (Georgia World Version) and Silica Terrell Keasler/Serena Taylor Keasler Tunestool (South Carolina World Version) as Timmy Turner
- Donald Jared Martin as Cosmo Cosma
- Jeffrey Gine Brunson as Wanda Fairywinkle-Cosma
- Victoria Lionne Martin and Oswald Brooke Keasler/Violet Taylor Keasler Tunestool as Denzel Crocker
- Orlando Kacey Mangram and Ashlyn Joseph Scott as Jorgen Von Strangle
- Jason David Mangram and Dianna Leigh Keasler (South Carolina World Version) as Chester McBadbat
- Katherine Elvin Mangram and Dianna Leigh Keasler (Georgia World Version) as A.J.
- Michael Terrell Keasler and Patrick Joshua Keasler as Mr. Turner
- Michelle Taylor Keasler and Shellyn Marie Keasler as Mrs. Turner
- Amy Maurice Scott as Vicky The Babysitter
- Ursula as Professor Calamitous
- Pete as Shirley
- Megara as Betty Quinlan
- Charlie Taylor Martin as Trixie Tang