Cast[]
- Silica Terrell Keasler/Serena Taylor Keasler Tunestool (Georgia World Version) and Silica Terrell Keasler/Serena Taylor Keasler Tunestool (South Carolina World Version) as Jimmy Neutron
- Donald Jared Martin and Jeffrey Gine Brunson as Carl Wheezer
- Charlie Taylor Martin as Sheen Estevez
- Katherine Elvin Mangram, Dianna Leigh Keasler (South Carolina World Version), and Dianna Leigh Keasler (Georgia World Version) as Cindy Vortex
- Jason David Mangram as Libby Folfax
- Helen Alice Burke as Goddard
- Michelle Taylor Keasler and Shellyn Marie Keasler as Judy Neutron
- Michael Terrell Keasler and Patrick Joshua Keasler as Hugh Neutron
- Sonic as Timmy Turner
- Chris as Cosmo Cosma
- Helen as Wanda Fairywinkle-Cosma
- Dr. Eggman as Denzel Crocker
- G.U.N. Commander as Jorgen Von Strangle
- Tails as Chester McBadbat
- Knuckles as A.J.
- Jules Hedgehog as Mr. Turner
- Bernadette Hedgehog as Mrs. Turner
- Amy as Vicky The Babysitter
- Orlando Kacey Mangram and Ashlyn Joseph Scott as Professor Calamitous
- Chaos as Shirley